Structural protective effects of glycosaminoglycans on articular distraction in joint diseases in animals

糖胺聚糖对动物关节疾病中关节牵引的结构保护作用

• 批准号: 22380170
• 负责人: OKUMURA Masahiro
• 金额: $ 12.73万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380170/
• 关键词: 関節疾患; グリコサミノグリカン軟骨細胞; 滑膜細胞; グリコサミノグリカン; 軟骨細胞

Intra-articular hyaluronic acid (HA) and subcutaneous pentosan polysulfate sodium (PPS) have been used for the management of pain and inflammation of osteoarthritis (OA) in humans and animals. As the results of this study, it was indicated that exogenous HA could stimulates both synovial fibroblasts and chondrocytes to produce endogenous long chain HA which contribute stabilization of cellular environment of articular chondrocytes. It was also suggested that PPS could inhibit interleukin (IL)-1β-induced phosphorylation of p38 and extracellular signal-regulated kinase (ERK), then suppress nuclear translocation of NF-κB and matrix metalloproteinase-3 production in cultured chondrocytes. on interleukin (IL)-1β stimulated chondrocytes. These data would translate the clinical efficacy of these molecules for clinical chondroprotective effects of HA and PPS in animals with OA.

关节内透明质酸(HA)和皮下多聚戊聚糖硫酸钠(PPS)已被用于治疗人和动物的骨性关节炎(OA)的疼痛和炎症。本研究结果表明，外源性HA可刺激滑膜成纤维细胞和软骨细胞产生内源性长链HA，有助于稳定关节软骨细胞的细胞环境。研究还表明，三七总皂甙可抑制白细胞介素1β诱导的p38和细胞外信号调节激酶的磷酸化，进而抑制培养的软骨细胞中核因子κB的核转位和基质金属蛋白酶3的产生。白细胞介素1(IL-1)β刺激软骨细胞。这些数据将解释这些分子对HA和PPS临床软骨保护作用的临床疗效。

项目成果

clinical efficacy and its mechanism to restore synovial fluid quality、The transient effects of COX-2 inhibitor on osteogenic differentiation in canine bone marrow-derived mesenchymal stem cells

临床疗效及其恢复滑液质量的机制，COX-2抑制剂对犬骨髓间充质干细胞成骨分化的短暂影响

• 发表时间: 2013
• 作者: NunomuraS;ShimadaS;Kametani Y;et al.;眞鍋昇;Oh N
• 通讯作者: Oh N

犬の関節疾患Update

狗关节疾病更新

• 发表时间: 2011
• 作者: 佐々木良輔;田島誉士;奥村正裕
• 通讯作者: 奥村正裕

ATRIX METALLOPROTEINASE-2 and -9 ACTIVITIES IN OSTEOARTHRITIC SYNOVIAL FLUIDS IN THOROUGHBRED HORSES

纯种马骨关节炎滑液中 ATRIX 金属蛋白酶-2 和 -9 的活性

• 发表时间: 2011
• 作者: 中塚一将;齋藤茂;高橋賢次;富永真琴;太田利男;河村麻紀;OKUMURA M
• 通讯作者: OKUMURA M

Divergent diagnosis from arthroscopic findings and identification of CPII and C2C for detection of cartilage degradation inhorses.

关节镜检查结果的不同诊断以及用于检测马软骨退化的 CPII 和 C2C 的识别。

• 发表时间: 2010
• 期刊: Japanese Journal of Veterinary Research
• 影响因子: 0.4
• 作者: Shiina T.;Shima T.;Masuda K.;Hirayama H.;Iwami M.;Takewaki T.;Kuramoto H.;Shimizu Y.;Lettry V
• 通讯作者: Lettry V

犬の骨折治療時の非ステロイド性抗炎症薬投与骨折治癒とシクロオキシゲナーゼ阻害について

关于犬骨折治疗期间使用非甾体抗炎药的骨折愈合和环氧合酶抑制

• 发表时间: 2011
• 作者: Ferens;D.M.;et. al;Kametani Y;加藤 肇・田島誉士;奥村正裕
• 通讯作者: 奥村正裕