Heparanase and extracellular matrices regulate cellular trafficking and function of inflammatory immune cells.

局部炎症的调节过程是通过细胞外基质的降解酶，特别是对硫酸乙酰肝素和肝素酶的降解或缩小来进行的。乙酰肝素酶参与了中性粒细胞和单核细胞在小鼠背部气囊的局部炎症以及体外移行实验中的外溢。酶的活性可能通过酶分子的不同定位来调节。肥大细胞分泌颗粒中颗粒肝素的裂解加速了颗粒物质从细胞外基质中的释放。从数据中，乙酰肝素酶的作用被令人信服地表明，作为一种关键的酶在炎症的诱导和持续时间。

Regulatory process of local inflammation is studied via degradation or downsizing of extracellular matrices by their degrading enzymes, especially on heparan sulfate and heparanase. Heparanase is involved in extravasation of neutrophils and monocytes in a local inflammation in mouse dorsal air pouches as well as in in vitro transmigration assay. Enzyme activity is likely to be regulated by differential localization of the enzyme molecules. Cleavage of granular heparin in the secretory granules of mast cells accelerates the release of granular materials from extracellular matrices. From the data, roles of heparanase are convincingly shown as a critical enzyme in induction and duration of inflammation.