Investigation of molecular pathology of Down syndrome by high efficient system

为了了解唐氏综合征的分子病理，我们建立了与人类21号染色体同源的16部分三体小鼠模型的高效系统。我们成功地建立了1)含有部分小鼠16号染色体片段的禽细胞，2)含有从禽细胞中提取的额外部分小鼠16号染色体片段的小鼠胚胎干细胞，以及3)这些胚胎干细胞的小鼠。这些资源将极大地促进唐氏综合症的研究。

To understand the molecular pathology of Down syndrome, we established a high efficient system in that mouse models with partial trisomy 16 which is syntenic to human chromosome 21. We successfully established 1) Avian cells harboring partial mouse chromosome 16 segments, 2) Mouse ES cells harboring extra partial mouse chromosome 16 derived from the avian cells, and 3) Mice from those ES cells. These resources should greatly contribute to Down syndrome studies.