Development of selective chemiluminescence assay for biologicalquinones and its application to clinical investigation

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Quinones are interesting compounds which have several important roles in biological functions such as mitochondrial electron transport chain and blood coagulation. On the other hand, quinones are regarded as a class of toxins which can cause a variety of hazardous effects on living health by the covalent binding to the protein and DNA, or the generation of reactive oxygen species through the redox cycle in biological system. In this study, sensitive and selective determination methods for biological quinones were developed based on the specific photoreaction and redox reaction of quinone and applied to biological samples to evaluate the usefulness of the developed method in clinical investigation.