Worksite-based cohort study on risk factors for non-communicable disease in Japan

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We carried out a worksite-based cohort study in an attempt to identify risk factors and novel markers of cardiovascular disease in recent Japanese population. Civil servants of a local government located in central Japan (n=6,648) were followed, and 59 incident coronary heart diseases, 47 strokes, 430 diabetes, and 1,599 hypertension were ascertained during the entire observation period (approximately 10 years). Overweight, hypertension, and current smoking were significantly positively associated with higher incidence of cardiovascular disease. Low adiponectin and high CRP blood levels, current smoking, breakfast skipping, and positive family history were associated with higher diabetes incidence. Novel biomarkers were obtained by AlphaLISA. We also performed questionnaire survey and collected additional blood and urine sample for the remaining and new cohort participants (n=6,046).