Potential mechanisms and therapeutic strategies of sarcopenia

为探讨骨髓干细胞和运动对增龄性骨骼肌萎缩和无力(肌质疏松症)的影响，将8周龄加速衰老倾向小鼠(SAMP10)移植野生型(C57BL/6)骨髓。对照组、非移植组和移植组SMAP10从25周龄开始随机分为运动训练组和非运动训练组。在40周龄时，进行肌肉重量、耐力和组织生化分析，为骨髓干细胞分化为骨骼肌细胞提供证据。野生型小鼠的骨髓移植改善了年龄相关的骨骼肌萎缩和无力(骨质疏松症)，提示骨髓细胞的老化可能是SAMP10骨质疏松症的原因之一。此外，运动还可以通过阻止SAMP10中肌肉蛋白的降解和线粒体的激活来预防骨骼肌减少。

To examine the effect of bone marrow stem cells as well as exercise on the age-associated skeletal muscle atrophy and weakness (sarcopenia), senescence-accelerated-prone mouse (SAMP10) were transplanted with bone marrow of wild-type (C57BL/6) at 8 weeks of age. Control non-transplant and transplant SMAP10 were randomly assigned to 2 groups with or without exercise training (from 25 weeks of age). At 40 weeks of age, muscle weight, endurance capacity, and the tissue biochemical analysis were carried out.These studies provide the evidences that the bone marrow-derived stem cells differentiate into skeletal muscle cells. Bone marrow transplantation of wild type mice improves the age-associated skeletal muscle atrophy and weakness (sarcopenia), suggesting that aging of bone marrow cells may contribute to the cause of sarcopenia of SAMP10. In addition, exercise can prevent sarcopenia through the prevention of muscle protein degradation and mitochondrial activation in SAMP10.