Relationship between bioiron and neurodegenerative disease investigated through the proton relaxation rate by MRI

我们利用观察到的人脑水的表观横向弛豫速率R2 <$t、铁浓度[Fe]和大分子质量分数fM的关系（R2 <$t = α[Fe] + βfM + γ，α，β，γ是系数）开发了一种体内铁成像方法。与健康受试者相比，患有浆细胞球蛋白血症的患者获得的铁图像显示所有脑区的铁浓度增加约4倍。我们还阐明了上述关系在1.5 - 7 T的宽磁场范围内是有效的。α、β、γ的场依赖性变化为揭示人脑的弛豫机制提供了线索

We developed an in vivo iron imaging method using a relationship of the observed apparent transverse relaxation rate, R2 † of human brain water, the iron concentration, [Fe], and the macromolecular mass fraction, fM (R2 † = α[Fe] + βfM + γ, α, β, γ are coefficients). Iron image obtained with a patient with aceruloplasminemia showed approximately 4 times increase in the iron concentration compared with healthy subjects in all brain regions. We also clarified that the above relationship is valid at wide range of magnetic field from 1.5 to 7T. Field dependent change in α, β, γ gave us a clue to uncover the mechanism of relaxation in human brain