Development of novel cell-penetrating peptides for treatment of cancer pain

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TrkA, a protein locating at neuron or malignant cells, is known to have a relation to pain and proliferation of cancer cells. My previous studies revealed that IPTRK3, a novel inhibitor of TrkA activity which I developed, suppresses pain in rodents. In this study, I synthesized 4 more peptides (IPTRK4, IPTRK5, IPTRK6, IPTRK7) and examined their effect on TrkA activity, followed by the investigation of their effect on either proliferation of cancer cell or cancer pain in rodents. Both IPTRK3 and IPTRK5 showed antiproliferative effect on cancer together with suppressive effect on cancer pain.