Activation of regulatory T cells by oral inhabitant bacteria and relationship of their existence and growth of cancer

口腔细菌激活调节性T细胞及其与癌症的存在和生长的关系

• 批准号: 22390352
• 负责人: SHIBATA Ken-ichiro
• 金额: $ 11.07万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390352/
• 关键词: 炎症; ガン; 制御性T細胞; 抗腫瘍活性; 口腔細菌; 口腔レンサ球菌; リポタンパク質; B16メラノーマ; NK細胞; TLR2; Toll-like receptor; リポペプチドFSL-1; 腫瘍

Both wild-type (WT) and lipoprotein-deficient (dLP) strains of oral streptococci, S. mutans and S. gordonii, increased the proliferation of CD4+CD25+Foxp3+ regulatory T cells, but reduced their suppressive activity. However, the presence of lipoprotein was not involved in these activities.WT strain of S. gordonii suppressed the growth of B16 melanoma in C57BL/6 mice, whereas dLP strain did not, suggesting that the presence of lipoprotein plays an important role in the anti-tumor activity. In addition, it was found that NK cells, but not cytolytic T cells, were involved in the anti-tumor acitivity.

口腔链球菌野生型（WT）和脂蛋白缺陷型（dLP）菌株，S。和S. gordonii，增加了CD 4 + CD 25 + Foxp 3+调节性T细胞的增殖，但降低了它们的抑制活性。然而，脂蛋白的存在并不参与这些活动。gordonii株抑制C57 BL/6小鼠B16黑色素瘤的生长，而dLP株则没有，这表明脂蛋白的存在在抗肿瘤活性中起重要作用。此外，还发现NK细胞而非溶细胞性T细胞参与了抗肿瘤活性。

项目成果

Involvement of suppressor of cytokine signaling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signaling by the murine C-type lectin SIGNR1-mediated signaling

细胞因子信号传导抑制因子 1 介导的 MyD88 适配器样蛋白降解参与小鼠 C 型凝集素 SIGNR1 介导的信号传导抑制 Toll 样受体 2 介导的信号传导

• DOI: 10.1111/j.1462-5822.2011.01695.x
• 发表时间: 2012
• 期刊: Cellular Microbiology
• 影响因子: 3.4
• 作者: M Ohtani;M Iyori;A Saeki;N Tanizume;T Into;A Hasebe;Y Totsuka;K Shibata
• 通讯作者: K Shibata

In vivo anti- and pro-tumour activities of the TLR2 ligand FSL-1

• DOI: 10.1016/j.imbio.2011.02.006
• 发表时间: 2011-08-01
• 期刊: IMMUNOBIOLOGY
• 影响因子: 2.8
• 作者: Kiura, Kazuto;Hasebe, Akira;Shibata, Ken-ichiro
• 通讯作者: Shibata, Ken-ichiro

口腔連鎖球菌の抗腫瘍活性

口腔链球菌的抗肿瘤活性

• 发表时间: 2012
• 作者: 原博志;佐伯歩;長谷部晃;柴田健一郎
• 通讯作者: 柴田健一郎