GENETIC AND ENVIRONMENTAL FACTORS INVOLVED IN SLEEP BRUXISM

睡眠磨牙症涉及的遗传和环境因素

• 批准号: 22390363
• 负责人: ISHIGAKI Shoichi
• 金额: $ 10.23万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390363/
• 关键词: 顎口腔機能学; 睡眠時ブラキシズム; 双生児研究; 遺伝学; 顎口腔機能異常; ライフスタイル; 遺伝要因; 環境要因

The objective was to reveal the importance of genetic and environmental factors involved in sleep bruxism. Twins were recruited from the Twin Mothers Club Japan through the Twin Research Center, Osaka University Graduate School of Medicine. Subjects consisted of 84 twins (42 twin pairs, mean age = 22.3± 6.8 yrs.). The total numbers of nocturnal electromyographic activities of the left temporal muscle were recorded with a portable automatic sleep bruxism analyzer. The recordings were carried out for three consecutive nights. The quantitative genetic statistics based on the structural equation modeling was carried out. The result of covariance structure analysis showed that the additive genetic effect was 0.42 and the unique environmental effect was 0.58. According to the result obtained from the present study genetic factors could be considered as a significant contributing factor for the initiation of sleep bruxism. However, the estimated environmental effect at 0.58 suggests the importance of individual evaluation of patients with sleep bruxism.

目的是揭示睡眠磨牙症的遗传和环境因素的重要性。双胞胎是通过大坂大学医学研究生院双胞胎研究中心从日本双胞胎母亲俱乐部招募的。受试者包括84对双胞胎（42对双胞胎，平均年龄= 22.3± 6.8岁）。用便携式磨牙症自动分析仪记录左侧颞肌夜间肌电活动总数。记录连续进行了三个晚上。采用结构方程模型进行了数量遗传统计。协方差结构分析结果表明，加性遗传效应为0.42，唯一环境效应为0.58。根据本研究的结果，遗传因素可以被认为是一个显着的影响因素，为启动睡眠磨牙症。然而，0.58的估计环境效应表明对睡眠磨牙症患者进行个体评估的重要性。

项目成果

顎関節症の症型発現における精神心理学的因子の関与

心理心理因素参与颞下颌关节紊乱的表现

• 发表时间: 2011
• 作者: 石垣尚一;高岡亮太;福田修二;内田昌範;矢谷博文
• 通讯作者: 矢谷博文

統合大調症患者における痛覚感受性の変化

精神分裂症患者疼痛敏感性的变化

• 发表时间: 2010
• 作者: 中江文;橋本亮太;前田尚悟;奥知子;安達友紀;福本素由己;大井一高;安田由華;山森英長;酒井規広;阪上学;石垣尚一;上出寛子;萩平哲;武田雅俊;柴田政彦;眞下節
• 通讯作者: 眞下節

The 14th Scientific Meeting of the Asian Academy of Craniomandibular Disorders (October 5-7, 2012, Taipei, Taiwanにて開催)における発表演題(学会発表欄(2))が,優秀ポスター発表賞(第3位)を受賞した

论文题目（会议报告部分（2））在亚洲颅颌骨疾病学会第14届科学会议（2012年10月5日至7日，台湾台北）上获得优秀海报展示奖（第三名）。

Preliminary analysis of genetic and environmental factors involved in sleep bruxism in twins

双胞胎睡眠磨牙症遗传及环境因素的初步分析

• 发表时间: 2012
• 作者: Takaoka R;Ishigaki S;Hayakawa K;Yatani H
• 通讯作者: Yatani H

定量的感覚検査(QST)の口腔領域における活用について

关于口腔区域定量感官测试（QST）的使用

• 发表时间: 2012
• 作者: Nakamura K;Ishiyama K;Ikai H;Kanno T;Sasaki K;Niwano Y;Kohno M;石垣尚一
• 通讯作者: 石垣尚一