Visualization of the sexual differentiation in the sexually dimorphic nucleus of the preoptic area.

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The sexually dimorphic nucleus in the preoptic area (SDN-POA) is larger in males than in females, however the mechanism of sexual differentiation of this structure remains largely unknown, except that androgen and/or estrogen during perinatal period cause the establishment of male-typical nuclei. We have shown recently that enhanced green fluorescent protein (EGFP) is expressed in the SDN-POA under the control of an estrogen receptor α gene promoter. The present study suggested that neural migration plays a key role in the sexual differentiation of the SDN-POA to visualize the nucleogenesis of the SDN-POA in vivo and in vitro.