Preparation of retina-targeted siRNA delivery system possessing stability in blood

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The transferrin(Trf)-modified liposomes which encapsulates nucleic acids such as siRNA and has stability in blood stream is developed for effective gene delivery to the posterior segment of eye (particularly retina) which has been known to be hard to deliver substances from blood stream. The results in vivo and in vitro study suggestthat the system is available as non-invasive application such as eye drop and could be added light- and thermo-activating function by improving components of lipids.