Interaction of regular exercise and caloric restriction for the DNA repair system

本研究旨在探讨低强度规则运动与40%热量限制对DNA修复系统的相互作用。仅通过运动或热量限制，核DNA中的氧化应激水平就会升高，而两者结合后，这种水平就会消失。此外，无论是否限制热量摄入，有规律的运动本身都能显著减轻线粒体DNA的氧化损伤。然而，在12周的干预中，DNA修复酶的表达没有显著变化。可以想象，习惯性的低强度运动和热量限制可能不会影响DNA修复系统中酶表达的反应性。

The purpose of this study was to investigate the interaction of low intensity regularexercise and 40% caloric restriction for DNA repair system. Oxidative stress level innuclear DNA was elevated by exercise or caloric restriction alone, and it disappearedby the combination of both. Additionally, a regular exercise itself markedly attenuatesoxidative damage in mitochondrial DNA, regardless of a caloric restriction. However,there were no significant changes in DNA repair enzyme expression by the 12-weekintervention. It is conceivable that the habitual low intensity exercise and caloricrestriction may not have an influence on the responsiveness of the enzyme expression ina DNA repair system.