Study on physical and mental fatigue using biomarkers in urine and brain.

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It is said that approximately two thirds of working population in Japan may be tired of working. The study of fatigue makes a contribution to the quality of life of the people. In this study, to investigate the difference between physical and mental fatigue, and the degree of both fatigue, we examined these biomarkers. The analysis of urine from physical or mental stress-loaded experimental animals, rats suggests that hydrogen peroxide, a reactive oxygen species is at least a kind of biomarker for physical fatigue. We will also analyze marker proteins and gene expressions related to fatigue using RNA-seq of mRNA from rat brain.