Antidepressant and anxiolytic effects of physical exercise and brain plasticity

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A great number of studies have suggested that physical exercise can reduce the incidence and symptoms of stress-related psychiatric disorders such as depression and anxiety through exercise-induced neuroplasticity, but the underlying neural mechanisms are not yet fully understood. In the present study, we examined how physical exercise mediates the stress-related psychiatric disorders, and considered the exercise parameters that result in the most favorable changes in brain plasticity. The results of this study suggested that physical exercise with less stress, such as mild or voluntary exercise, may be most efficient for preventing the incidence of stress-related psychiatric disorders.