Effect of meal on postprandial change in heart rate, blood pressure and cardiac autonomic activity

一些流行病学数据表明餐后血流动力学变化的有害影响，包括心率、血压和心脏自主神经活动。提高对此类血流动力学变化的认识，应建议调整饮食，并提供能够限制饮食引起的有害血流动力学后果的治疗方法。研究的目的有三个：(1)阐明进餐量对餐后血流动力学变化的影响(2)比较一天中不同进餐时间餐后血流动力学变化的差异(3)比较糖尿病患者与健康人的餐后血流动力学变化。营养摄入后胰岛素升高与餐后血流动力学变化有关，而食量可能对餐后血流动力学变化起重要作用。夜间进食（晚上11点）会影响夜间心率和心脏自主活动的节奏，导致早晨血压升高。在相对早期的糖尿病患者中，可以观察到餐后中枢血压和肱血压的降低。

Several epidemiological data suggest the deleterious influence of postprandial hemodynamic changes, including heart rate, blood pressure and cardiac autonomic activity. Improving the knowledge of such hemodynamicchanges should lead to advise diet modifications and to offer treatments able to limitmeal-induced deleterious hemodynamic consequences. The purpose of the investigation was threefold:(1) to clarify the effect of meal amount on postprandial hemodynamic changes(2) to compare the difference of postprandial hemodynamic changes at different dinner times of the day(3) to compare postprandial hemodynamic changes in diabetics with those of healthy persons. The increase in insulin after nutrient intake was associated with postprandial hemodynamic changes and meal amount might play the important role on postprandial hemodynamic changes. Nocturnal eating (at 11pm) affected the rhythm of heart rate and cardiac autonomic activity during night resulting the high blood pressure in the morning. In patients with diabetes mellitus in the relatively early stage, postprandial decrease in central blood pressure as well as in brachial blood pressurewas observed.