Anti-aging effects of melatonin on age-related deficits in learningand memory

本实验观察了褪黑素对11月龄（中年）至19月龄（老年）小鼠学习记忆能力的影响。我们还检测了8-羟基-2 '-脱氧鸟苷（8-OHdG）在这些小鼠脑中的积累，作为氧化应激的指标。与未治疗的老年小鼠相比，褪黑素治疗的老年小鼠表现出改善的记忆力和减少的8-OHdG积累。这些数据表明，褪黑激素可能通过其抗氧化作用减轻与年龄相关的学习和记忆障碍。

We examined the effects of melatonin on age-related deficits in learning andmemory in the mice which were given drinking water with/without melatonin for 8 month from 11months old (middle age) to 19 months old (old age). We also examined the accumulation of8-hydroxy-2'-deoxyguanosine (8-OHdG) in the brain of these mice as an index of oxidative stress. Themelatonin treated old mice showed improved memory and reduced accumulation of 8-OHdG whencompared with untreated old mice. These data suggested the possibility that melatonin attenuatesage-related deficits in learning and memory through its anti-oxidative action.