Anti-aging effects of melatonin on age-related deficits in learningand memory

从11个月大（中年）到19个月大（老年），我们研究了褪黑素对小鼠年龄相关的学习和记忆缺陷的影响。我们还检测了作为氧化应激指标的8-羟基-2'-脱氧鸟苷（8-OHdG）在这些小鼠大脑中的积累。与未接受褪黑素治疗的老年小鼠相比，接受褪黑素治疗的老年小鼠表现出记忆力改善和8-OHdG积累减少。这些数据表明，褪黑激素可能通过其抗氧化作用减弱与学习和记忆相关的缺陷。

We examined the effects of melatonin on age-related deficits in learning andmemory in the mice which were given drinking water with/without melatonin for 8 month from 11months old (middle age) to 19 months old (old age). We also examined the accumulation of8-hydroxy-2'-deoxyguanosine (8-OHdG) in the brain of these mice as an index of oxidative stress. Themelatonin treated old mice showed improved memory and reduced accumulation of 8-OHdG whencompared with untreated old mice. These data suggested the possibility that melatonin attenuatesage-related deficits in learning and memory through its anti-oxidative action.