Novel role of glucose receptor and orexin neuron as sensor of cerebral ischemia

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In this study, we determined the effects of intra-hypothalamic administration of orexin-A on the development of post-ischemic glucose intolerance, including changes in insulin signaling and ischemic neuronal damage.In conclusion, regulation of post-ischemic glucose intolerance by intra-hypothalamic administration of orexin-A significantly suppressed cerebral ischemic neuronal damage. These findings provide some insight into the therapeutic effectiveness of the use of this endogenous neuropeptide. These results from the present study may be helpful for the development of new agents and strategies for clinical treatment of cerebral stroke.