Fundamental research for the countermeasure against viral infectious disease by oral intake of ・-carotene

减少谷氨酰胺（GSH）在免疫细胞中的影响力水平。在目前的研究中，我们关注的是胡萝卜素的影响，即胡萝卜素对谷氨酸-半胱氨酸-合成酶（GCL）的性质的影响，其中胡萝卜素被纳入GSH合成中。实验与GCL特定抑制剂、翻译抑制剂和转录抑制剂揭示了某些胡萝卜素-用转录的上级规范对GCL进行新合成，结果在对内源GSH水平的增强中发现了。

The intracellular level of reduced glutathione (GSH) in immune cells has influences on the immunity. In the present study, we focused on the effect of carotenoids such as ・-carotene on the properties of glutamate-cysteine-ligase (GCL) which is involved in GSH synthesis. Experiments with a GCL specific inhibitor, a translation inhibitor, and a transcription inhibitor revealed that certain caroteonids including ・-carotene induce de novosynthesis of GCL accompanied with the up-regulation of transcription, which resulted in the enhancement of the intracellular GSH level.