Effect of low-dose aloe emodin on the development of colorectal tumors in Min mice

点击翻译按钮获取中文摘要

Aloe emodin (AE) is a hydroxyanthraquinone compound that is present in some medicinal plants such as Cassia, Rheum, and Aloe. AE has been reported to have anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. We investigated the cancer chemopreventive effects of low-dose AE on the development of colorectal tumors in ApcMin/+ mice without or with dextran sodium sulfate (DSS). As a result, feeding with low-dose (5, 10 or 50 ppm) AE reduced the development of colorectal tumors in ApcMin/+ mice without or with DSS, although this was not dose-dependent. These results suggest that dietary administration of low-dose (somewhere between 5 and 50 ppm) AE may have chemopreventive effects especially against colitis-related colorectal tumor development in ApcMin/+ mice.