Investigation of food ingredients with anti-obese activity through inhibition of active ghrelin production
Investigation of food ingredients with anti-obese activity through inhibition of active ghrelin production
批准号:
22500794
负责人:
KARIYAZONO Hiroko
金额:
$1.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Ghrelin is a gastric peptide hormone with orexigenic activity; therefore, inhibition of its production might prevent obesity. To identify candidate inhibitors of active ghrelin production, we established the AGS-GHRL8 cell line by transfection of ghrelin cDNA into AGS cells originating from human gastric carcinoma tissue. Heptanoic, oleic, and eicosapentaenoic acids inhibited active ghrelin secretion from AGS-GHRL8 cells, whereas acetic and butyric acids did not. Thus, oleic and eicosapentaenoic acids would be candidate food ingredients with anti-obese activity through inhibition of active ghrelin production.
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咽頭がん細胞KCP-4のシスプラチン耐性機構における転写因子NF-κBおよびp53の関与
转录因子NF-κB和p53参与咽癌细胞KCP-4顺铂耐药机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大磯茂, 松永直子, 池田龍二, 中村和男, 武田泰生, 秋山伸一, 仮屋薗博子]
通讯作者:
仮屋薗博子
DOI:
10.3892/or.2012.1801
发表时间:
2012-07-01
期刊:
ONCOLOGY REPORTS
影响因子:
4.2
作者:
[Oiso, Shigeru, Ikeda, Ryuji, Kariyazono, Hiroko]
通讯作者:
Kariyazono, Hiroko
Investigation of decomposition products of tris (2-ethylhexyl) trimellitate, a plasticizer
增塑剂偏苯三酸三(2-乙基己基)酯分解产物的研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Iwase H, Saito H, Oiso S, Kariyazono H, Nishizawa Y, Sakurai K, Takahama K, Nakamura K]
通讯作者:
Nakamura K
Inhibitory effects of some fatty acids on active ghrelin production in a stable ghrelin-expressing AGS-GHRL8 cell line.
某些脂肪酸对稳定表达 ghrelin 的 AGS-GHRL8 细胞系中活性 ghrelin 产生的抑制作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamaguchi Y, Oiso S, Nobe M, Kariyazono H.]
通讯作者:
Kariyazono H.
Establishment of a cell-based assay system for exploring inhibitors of active ghrelin production.
建立基于细胞的检测系统,用于探索活性生长素释放肽产生的抑制剂。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Oiso S, Nobe M, Nakamura K, Kariyazono H.]
通讯作者:
Kariyazono H.
共 33 条
Elucidation of octanoylated ghrelin secretion mechanism targeted towards regulating appetite and obesity
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批准号:16K01848
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2016
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负责人:KARIYAZONO Hiroko
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依托单位: