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Investigation of food ingredients with anti-obese activity through inhibition of active ghrelin production

Investigation of food ingredients with anti-obese activity through inhibition of active ghrelin production
通过抑制活性生长素释放肽的产生来研究具有抗肥胖活性的食品成分
批准号:
22500794
负责人:
KARIYAZONO Hiroko
金额:
$1.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

KARIYAZONO Hiroko的其他基金

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中文摘要
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英文摘要
Ghrelin is a gastric peptide hormone with orexigenic activity; therefore, inhibition of its production might prevent obesity. To identify candidate inhibitors of active ghrelin production, we established the AGS-GHRL8 cell line by transfection of ghrelin cDNA into AGS cells originating from human gastric carcinoma tissue. Heptanoic, oleic, and eicosapentaenoic acids inhibited active ghrelin secretion from AGS-GHRL8 cells, whereas acetic and butyric acids did not. Thus, oleic and eicosapentaenoic acids would be candidate food ingredients with anti-obese activity through inhibition of active ghrelin production.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [大磯茂, 松永直子, 池田龍二, 中村和男, 武田泰生, 秋山伸一, 仮屋薗博子]
通讯作者: 仮屋薗博子
DOI: 10.3892/or.2012.1801
发表时间: 2012-07-01
期刊: ONCOLOGY REPORTS
影响因子: 4.2
作者: [Oiso, Shigeru, Ikeda, Ryuji, Kariyazono, Hiroko]
通讯作者: Kariyazono, Hiroko
Investigation of decomposition products of tris (2-ethylhexyl) trimellitate, a plasticizer
增塑剂偏苯三酸三(2-乙基己基)酯分解产物的研究
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Iwase H, Saito H, Oiso S, Kariyazono H, Nishizawa Y, Sakurai K, Takahama K, Nakamura K]
通讯作者: Nakamura K
Inhibitory effects of some fatty acids on active ghrelin production in a stable ghrelin-expressing AGS-GHRL8 cell line.
某些脂肪酸对稳定表达 ghrelin 的 AGS-GHRL8 细胞系中活性 ghrelin 产生的抑制作用。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yamaguchi Y, Oiso S, Nobe M, Kariyazono H.]
通讯作者: Kariyazono H.
33
    Elucidation of octanoylated ghrelin secretion mechanism targeted towards regulating appetite and obesity
    • 批准号:
      16K01848
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.58万
    • 财政年份:
      2016
    • 负责人:
      KARIYAZONO Hiroko
    • 依托单位: