Analysis of physiological role of Wnt pathway activation inducedby Krtap13, a novel LRP6 binding protein
Analysis of physiological role of Wnt pathway activation inducedby Krtap13, a novel LRP6 binding protein
批准号:
22501008
负责人:
YANAGAWA Shin-ichi
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Keratin associated protein (Krtap) 13 binds to LRP6, a co-receptor for Wnt. Surprisingly, Krtap13 overexpression markedly stimulates Wnt signaling. Krtap13 induces co-clustering of LRP6 and Dvls, thereby recruiting Axin to the plasma membrane that leads to activation of Wn signaling. Transgenic mice were generated to analyze effect of Krtap13 overexpression in vivo.
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Analysis of Keratin-Associated Protein13-Induced Activation of Canonical Wnt Pathway in vivo
体内角蛋白相关蛋白 13 诱导的经典 Wnt 通路激活分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M, 柳川伸一, 柳川伸一, 柳川伸一, 柳川伸一]
通讯作者:
柳川伸一
Analysis of Keratin-associated proteinl3-induced activation of canonical Wnt signaling pathway in vivo
体内角蛋白相关蛋白l3诱导的经典Wnt信号通路激活分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M, 柳川伸一, 柳川伸一, 柳川伸一, 柳川伸一, 柳川伸一]
通讯作者:
柳川伸一
20年前のWnt研究の現場はどうだったか
20年前的Wnt研究场景是什么样的?
DOI:
--
发表时间:
2013
期刊:
細胞工学
影响因子:
--
作者:
[Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M, 柳川伸一]
通讯作者:
柳川伸一
20年前のWnt研究の現場は、どうだったか
20年前的Wnt研究场景是什么样的?
DOI:
--
发表时间:
2013
期刊:
細胞工学
影响因子:
--
作者:
[Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M, 柳川伸一, 柳川伸一]
通讯作者:
柳川伸一
Analysis of Keratin associated protein13-induced activation of canonical Wnt pathway in vivo.
角蛋白相关蛋白 13 诱导的体内经典 Wnt 通路激活分析。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M, 柳川伸一, 柳川伸一, 柳川伸一]
通讯作者:
柳川伸一
共 9 条
Analysis of molecular mechanisms underlying Grb10-mediated suppression of the Wnt signaling pathway
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批准号:19570127
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2007
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负责人:YANAGAWA Shin-ichi
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依托单位:
RNAi-based genome-wide search for genes constituting Wnt signaling pathway by using Drosophila tissue culture cells
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批准号:17570111
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:YANAGAWA Shin-ichi
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依托单位:
Analysis of Casein kinase I function in the Wnt signal-mediated regulation of Armadillo family protein degradation.
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批准号:15570113
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2003
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负责人:YANAGAWA Shin-ichi
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依托单位:
Biochemical analysis of Wnt/Wingless signal transduction pathway with tissue culture system
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批准号:12680635
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:2000
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负责人:YANAGAWA Shin-ichi
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依托单位:
Functional analysis of truncated Notch 1 gene products generated by insertions of mouse mammary tumor proviruses in development of mouse lymphomas.
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批准号:09470084
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.76万
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财政年份:1997
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负责人:YANAGAWA Shin-ichi
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依托单位: