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Exploratory research on new tumor markers that are useful for a diagnosis of the early breast cancer and development of a simplified assay system

Exploratory research on new tumor markers that are useful for a diagnosis of the early breast cancer and development of a simplified assay system
对有助于早期乳腺癌诊断的新肿瘤标志物的探索性研究和简化检测系统的开发
批准号:
22501030
负责人:
KURONO Sadamu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We measured proteome in nipple discharge (ND) and nipple aspirate fluid like (NAF-L), which were collected from breast cancer and non-cancer patients, using two dimensional nano-LC-nanoelectrospray mass spectrometry (ESI-MS), and then 15 kinds of proteins were found as breast cancer candidate markers by various kinds of statistical technique. Furthermore, we have examined the expression of such protein candidate markers using histological stain and ELISA methods for validating as new breast cancer markers.
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会议论文
An Attempt to Quantitative Analysis for Clinical Proteomics by Nano LC-nano-ESI-SRM-MS Using Stable Isotope-labeled Iodoacetanilide as well as 19thN-Ethylmaleimide.
尝试使用稳定同位素标记的碘乙酰苯胺以及 19thN-乙基马来酰亚胺通过纳米 LC-nano-ESI-SRM-MS 进行临床蛋白质组学定量分析。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kurono, S., Kaneko, Y., Matsuura, S., and Niwayama, S.]
通讯作者: S.
乳癌の判定方法
如何判断乳腺癌
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
Protein Profile Analysis for Potential Breast Cancer Markers in Nipple Discharge by Nano-LC-ESI-Mass Spectrometry
通过纳米 LC-ESI 质谱法分析乳头溢液中潜在乳腺癌标志物
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Naoko Sueoka-Aragane, Akemi Sato,Kentaro Iwanaga, Naomi Kobayashi,Shinya Kimura,Eisaburo Sueoka, Yuka Kaneko]
通讯作者: Yuka Kaneko
Identification and Quantitative Analysis for Clinical Proteomics by LC-ESI/MS Using Stable Isotope-labeled Iodoacetanilide
使用稳定同位素标记的碘乙酰苯胺通过 LC-ESI/MS 进行临床蛋白质组学鉴定和定量分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [石丸神矢, 三森功士, 田中文明, 柴田浩平, 主藤朝也, 横堀武彦, 西田尚弘, 古後龍之介, 岩谷岳, 杉原健一, 森正樹, 黒野定]
通讯作者: 黒野定
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