Development of a biomarker for small intestinal mucosal injury following chemotherapy for gastric cancer and establishment of new method to prevent gastrointestinal adverse event

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To clarify the gastro-intestinal adverse event (mainly diarrhea) and morphological change of the small intestine after chemotherapy, we investigate the correlation between DAO activity and morphological change of small intestine by light microscopy, immuno-histochemistry (for PCNA and Ki67) and scanning electron microscopy. We also investigated that soluble dietary fiber could prevent the injury for small intestine. The conclusions are 1) DAO activity can indicate the small intestine injury after chemotherapy, and 2) soluble dietary fiber may have an effect to improve the small intestine injury.