Development of DDS which accumulate cancer cell by chemokines function in peritoneal carcinomatosis therapy

我们检测了几种趋化因子受体在人实体癌中的表达，如胃、结直肠、肝、卵巢癌细胞系。这些细胞系选择性地高水平表达CXCR4。在Boyden趋化小室中，这些细胞对CXCL12表现出明显的趋化反应。然而，在实时迁移活动监控设备中无法观察到这种响应。另一方面，这些细胞运动的灵活性增加。

We examined expression of several chemokine receptors in human solid cancer such as gastric, colorectal, liver, ovarian cancer cell lines. These cell lines selectively expressed CXCR4 at high levels. These cells showed significant chemotactic response to CXCL12 in Boyden chemotaxis chamber. However, this response could not be observed in Real-time migration activity monitoring device. On the other hand, flexibility of the kineticism of these cells increased.