Statistical modeling of dose response for the radiation effect analysis

用于辐射效应分析的剂量反应统计模型

• 批准号: 22510055
• 负责人: DATE Hiroyuki
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22510055/
• 关键词: 生物影響; 放射線作用機構; 放射線被ばく影響; 電子線トラック; 二本鎖切断; 細胞生存率; 放射線誘起バイスタンダー効果; 免疫蛍光染色法; 放射線被曝影響; 電離・励起クラスター; 非致死確率

The effects of radiation exposure on bio-cells were investigated by the Monte Carlo simulations of electrons and biologically active agents, and by the observation of DNA lesions in cell nuclei using immunofluorescent staining. The simulation study of electrons showed that the electron track structure created by the radiation affects strongly the lesion pattern in a cell. From a model analysis for the cell lethality and the observation of DNA lesions, it was found that the surviving fraction of cells is governed by the lesion number per cell following the Poisson statistics and the repair probabilities of the lesions.

通过电子和生物活性剂的Monte Carlo模拟，以及通过使用免疫荧光染色观察细胞核中的DNA损伤，研究了辐射暴露对生物细胞的影响。电子的模拟研究表明，由辐射产生的电子轨道结构强烈影响细胞中的损伤模式。从细胞致死率和DNA损伤观察的模型分析中，发现细胞的存活分数由遵循泊松统计的每个细胞的损伤数量和损伤的修复概率决定。

项目成果

Modeling of Radiation-Induced Bystander Effect with Re-emitting Signals Following the Poisson Statistics

遵循泊松统计的重新发射信号的辐射诱发旁观者效应建模

• 发表时间: 2012
• 作者: K. Sasaki;H. Date;T. Tsujiguchi;K. Wakui and A. Itoh
• 通讯作者: K. Wakui and A. Itoh

Trial Study of a New Model for Cell Surviving Fraction.

细胞存活分数新模型的试验研究。

• 发表时间: 2011
• 作者: Kosuke Wakui;Takahiro Kato;Kohei Sasaki and Hiroyuki Date.
• 通讯作者: Kohei Sasaki and Hiroyuki Date.

Theoretical Comparison between Availabilities of Single- and Fractionated- Irradiation Therapies.

单次放射治疗和分段放射治疗的可用性之间的理论比较。

• 发表时间: 2011
• 作者: M. Mizuta;S. Takao;H. Date;N. Kishimoto;H. Shirato.
• 通讯作者: H. Shirato.

Modeling of Clustering Properties of the Electron Processes in Bio-Tissues Exposed to Ionizing Radiation.

暴露于电离辐射的生物组织中电子过程的聚类特性的建模。

• 发表时间: 2011
• 作者: Yuji Yoshii;Kohei Sasaki;K.L. Sutherland;and Hiroyuki Date.
• 通讯作者: and Hiroyuki Date.

An Interpretation of the Survival Curve for Cells Exposed to X-rays.

暴露于 X 射线的细胞存活曲线的解释。

• 发表时间: 2010
• 作者: H. Date;T. Kato;K. Wakui.
• 通讯作者: K. Wakui.