Statistical modeling of dose response for the radiation effect analysis

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The effects of radiation exposure on bio-cells were investigated by the Monte Carlo simulations of electrons and biologically active agents, and by the observation of DNA lesions in cell nuclei using immunofluorescent staining. The simulation study of electrons showed that the electron track structure created by the radiation affects strongly the lesion pattern in a cell. From a model analysis for the cell lethality and the observation of DNA lesions, it was found that the surviving fraction of cells is governed by the lesion number per cell following the Poisson statistics and the repair probabilities of the lesions.