Induced Signal Transduction by Interaction between Nano-sized polymer Aggregates and Plasma Membrane of Cells

纳米聚合物聚集体与细胞质膜相互作用诱导信号转导

• 批准号: 22510120
• 负责人: NISHIKAWA Takehiro
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22510120/
• 关键词: ナノバイオ; ナノ材料; 生体機能利用; ナノ粒子; 細胞膜; エンドサイトーシス; カベオラ; 細胞内シグナル伝達; 両親媒性ポリシロキサン; 一酸化窒素合成酵素

n our research project supported by Grant-in-Aid for Scientific Research (C) (22510120), we studied how the expression level and phosphorylation of endothelial nitric oxide synthase (eNOS) are influenced when nanoparticles of amphiphilic polymer are endocytosed into vascular endothelial cells. We experimentally demonstrated that cellular uptake of the synthetic nanoparticles of polysiloxane can be processed assignals and result in the enhanced cellular responses (nitric oxide release). 交付決定額

n our research project supported by Grant-in-Aid for Scientific Research (C) (22510120), we studied how the expression level and phosphorylation of endothelial nitric oxide synthase (eNOS) are influenced when nanoparticles of amphiphilic polymer are endocytosed into vascular endothelial cells. We experimentally demonstrated that cellular uptake of the synthetic nanoparticles of polysiloxane can be processed assignals and result in the enhanced cellular responses (nitric oxide release). Delivery decisions

项目成果

単層膜リポソームを反応場とする遺伝子選択系の構築

以单层脂质体为反应场的基因选择系统的构建

• 发表时间: 2010
• 作者: 西川雄大;角南武志;松浦友亮;市橋伯一;四方哲也
• 通讯作者: 四方哲也

Quantitative Gene Screening System Based on Giant Unilamellar Lipsomes and Fluorescence Activated Cell Sorter

基于巨型单层脂质体和荧光激活细胞分选仪的基因定量筛选系统

• 发表时间: 2011
• 作者: Yuji Kunisada;Hirofumi Kishi;Fajarisandi Dimas;Melanie Yadao David;Hiroshi Nakanishi;Hideaki Kasai;Takuma Asari;Shigeo Hayashi;Takehiro Nishikawa
• 通讯作者: Takehiro Nishikawa

Interfacial Researches in Fundamental and Material Sciences of Oligo- and Polysaccharides

寡糖和多糖基础和材料科学的界面研究

• 发表时间: 2010
• 作者: Yasutomo;M ; Tsuji;T ; Mizuki;T ; Tsuji;M ; Kawasaki;H;T. Nishikawa (J. Kadokawa Ed.)
• 通讯作者: T. Nishikawa (J. Kadokawa Ed.)

リポソームを用いた遺伝子スクリーニングシステムの構築

利用脂质体构建遗传筛查系统

• 发表时间: 2011
• 作者: 西川雄大;角南武志;松浦友亮;市橋伯一;四方哲也
• 通讯作者: 四方哲也

単層膜リポソームとセルソーターを用いる遺伝子スクリーニングシステムの構築

使用单层脂质体和细胞分选仪构建遗传筛查系统

• 发表时间: 2011
• 作者: 西川雄大;角南武志;松浦友亮;市橋伯一;四方哲也
• 通讯作者: 四方哲也