Heme oxygenase strategy for circumventing environmental changes_fine tuning of activity

不同的生物物种，其生物学生态位不同，通常保留血红素降解酶，即血红素加氧酶(HO)，其中血红素是进行许多体内反应所必需的。我们从陆地哺乳动物、大鼠、海豚鱼、陆地植物、大豆和淡水蓝藻中制备了HOS，并比较了它们在不同反应条件下的血红素降解活性。结果发现，不同来源的HO在不同的反应条件下会在不同的反应阶段受到影响。

Different biological species, whose biological niches are different, commonly retain heme degradation enzyme, heme oxygenase (HO), where heme is indispensable for proceeding many in vivo reactions. We have prepared HOs from a land mammalian, rat, marine puffer fish, a land plant, soybean, and a freshwater cyanobacterium and compared their heme degradation activity under different reaction conditions. As a result, we have found that the HO from different origin is affected at different reaction stages under respective reaction conditions.