Characterization of small organic molecules with threshold-energy dissociation mass spectrometry

阈值能量解离质谱学的基本概念和框架已被应用于各种串联质谱计，包括四极杆仪器。通过对一些有机分子的裂解行为和阈值能的分析，为开发包括异构体在内的小分子的鉴定方法奠定了基础。结合阈值解离和离子迁移率串联质谱仪的综合分析策略被证明是表征同分异构体离子和裂解网络的一种很有前途的方法。

The basic concept and framework of threshold-energy dissociation mass spectrometry have been applied to various tandem mass spectrometers including quadrupole-type instruments. Analysis of fragmentation behavior of some organic molecules and threshold-energies allowed us to establish the basis for the exploitation of the method for identification of small molecules including isomers. An integrated analytical strategy including threshold dissociation and ion mobility tandem mass spectrometry was shown to be promising for characterization of isomeric ions and fragmentation networks.