Design and Functionality of MolecuIar Machines based on Peptide Helices

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In the present study, a variety of helix-based molecular machines that response to stimulus have been designed. These helical molecular machines based on protein-mimicking peptide backbones can induce a screw sense through external stimuli such as chiral additives, which are frequently found in bio-related compounds. The induced screw sense and its bias have been shown to depend largely on several factors such as peptide molecular structures and types of chiral additives. Here chiral signals generated in induction of such a helical screw sense can be detected. Thus the preset findings can also lead to design of functional molecular materials for sensing external stimuli.