The possibleprincipal function of neurohypophysial hormones

神经垂体激素可能的主要功能

• 批准号: 22570065
• 负责人: SAKAMOTO Tatsuya
• 金额: $ 2.66万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22570065/
• 关键词: 比較内分泌; 環境適応; バソトシン; イソトシン; トビハゼ; 環境; 神経行動; 脳; 国際研究者交流; アメリカ合衆国; ニュージーランド

Acclimation from marine to dilute environments constitutes among the most dramatic evolutionary transitions in the history of life. Such adaptations have evolved in multiple lineages, but studies of the mechanisms are limited to those using evolutionarily advanced Deuterostome (chordates) and Ecdysozoa (crustaceans). Here we examined the body-fluid homeostasis in the advanced Lophotrochozoa/mollusc, the other unexplored taxa, and its possible regulations byvasopressin/oxytocin superfamily peptides known to be implicated in fluid homeostasis in Chordata and Arthropoda. The hemolymph osmotic and ionic status in the euryhaline cephalopod (Octopus ocellatus) following transfer from normal seawater (30 ppt) to low (20 ppt) salinity indicate the hyperosmo- and hyperiono-regulatory abilities for more than 1 week, as in crustaceans and teleost fish. While ventilation frequency decreased by 1 day, Na+/K+-ATPase activity, which has been implicated in ion transport generally, was induced in two of the eight posterior gills after 1 week. Furthermore, the octopuses were intravenously injected with 1 or 100 ng/g octopressin or cephalotocin, cephalopod vasopressin/oxytocin orthologs. After 1 day, octopressin, not cephalotocin, decreased the hemolymph osmolality and Ca concentrations as well as urinary Na concentrations. These data provide evidence for convergent evolution in the hyper-ionoregulatory mechanisms and the coordination by conserved molecules.

从海洋环境到稀释环境的适应是生命史上最戏剧性的进化转变之一。这种适应已经在多个谱系中进化，但对机制的研究仅限于那些使用进化先进的后口动物（脊索动物）和蜕皮动物（甲壳动物）的研究。在这里，我们研究了先进的Lophotrochozoa/软体动物，其他未开发的类群，其可能的监管byprospersin/催产素超家族肽已知的流体稳态在脊索动物和节肢动物的体液稳态牵连。血淋巴的渗透和离子状态在广盐性头足类动物（章鱼ocellatus）从正常海水（30 ppt）转移到低（20 ppt）盐度表明hyperosmo和hyperiono的调节能力超过1周，在甲壳类和硬骨鱼。虽然通气频率下降了1天，Na+/K+-ATP酶活性，这已牵连在离子转运一般，诱导在两个后鳃后1周。此外，章鱼静脉内注射1或100 ng/g的章鱼加压素或头孢菌素，头足类动物加压素/催产素直向同源物。1天后，章鱼加压素，而不是头孢菌素，降低血淋巴渗透压和钙浓度以及尿钠浓度。这些数据为超离子调节机制的趋同进化和保守分子的协调提供了证据。

项目成果

Current studies at Ushimado Marine Institute

牛窗海洋研究所的研究现状

• 发表时间: 2011
• 作者: Edamatsu M;Date E;Ikeda N;Kondo Y;Ando M;塩尻信義;佐藤健太;原田明子;M.Uchiyama;大友一平;H. Takahashi,T. Sakamoto;芳賀健;Edamatsu M.;元山記子;塩尻信義;T. Sakamoto
• 通讯作者: T. Sakamoto

Morphological responses of mitochondria-rich cells to hypersaline environment in the Australian mudskipper, Periophthalmus minutus

澳大利亚弹涂鱼 Periothoughtmus minutus 富含线粒体的细胞对高盐环境的形态反应

• 发表时间: 2012
• 期刊: Zoological Science
• 影响因子: 0.9
• 作者: Itoki;N.;T.Sakamoto;M.Hayashi;T.Takeda;A.Ishimatsu
• 通讯作者: A.Ishimatsu

H. Sakamoto,H. Takahashi, K. Matsuda, M. Nishi, K. Takanami, M. Ogoshi, T. Sakamoto, M. Kawata

H.坂本，H.

• 发表时间: 2012
• 期刊: Front Biosci
• 作者: Edamatsu M;Hishikawa S;Kondo Y;Ando M;Rapid signaling of steroid hormones in the vertebrate nervous system
• 通讯作者: Rapid signaling of steroid hormones in the vertebrate nervous system

Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor

皮质醇通过糖皮质激素受体对青鳉食道细胞更新的双重体外作用

• 发表时间: 2011
• 期刊: Life Sci
• 影响因子: 6.1
• 作者: C. Takagi;H. Takahashi;H. Kudose;K. Kato;T. Sakamoto
• 通讯作者: T. Sakamoto

Embryonic development and larval behavior of the kissing loach (Parabotia curta): adaptations to an ephemeral, hypoxic environment

接吻泥鳅（Parabotia curta）的胚胎发育和幼虫行为：对短暂缺氧环境的适应

• 发表时间: 2011
• 期刊: Ichthyol Res
• 影响因子: 1.2
• 作者: T. Abe;T. Sakamoto
• 通讯作者: T. Sakamoto