Immune evasion mechanisms from NK immunity by cancer cell-surface O-glycans

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Most cancer cells are rejected by host tumor immunosurveillance systems. NK cells are the major effector lymphocytes in tumor rejection responses. However, malignat cancer cells take various strategies to evade tumor rejection systems by NK cells. Those cancer cells survive longer in host, resulting in the promotion of metastasis. We have identified a new immune evasion strategy by cancer cells. Some cancer cells use a certain type of cell-surface carbohydrates to evade NK cell attack, thereby increasing the chance to metastasize.In addition, we discovered a novel cell biological mechanism underlying the extravasation of metastatic cancer cells from blood vessels of the metastasis target organ.