Molecular and physiological functions of NDRG1 and NDRG4

我们以前产生NDRG 4缺陷小鼠表现出空间学习缺陷和脑缺血的脆弱性。这项研究表明，NDRG 4有助于维持脑内BDNF水平在正常范围内，这是神经细胞正常功能所必需的。我们鉴定了NDRG 4结合蛋白，其也与NDRG 1-NDRG 3相互作用。NDRG家族蛋白可能通过结合蛋白的功能来调节细胞活动。

We previously generated NDRG4-deficient mice that exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. This study revealed that NDRG4 contributed to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the normal functions of neuronal cells. We identified NDRG4-binding proteins, which also interacted with NDRG1-NDRG3. NDRG family proteins may regulate cell activities through the functions of the binding proteins.