Analysis of physiological role of SVIL for cytokinesis

我们发现超级绒毛蛋白（SVIL）在细胞分裂过程中定位于中央纺锤体。这种定位依赖于SVIL的Ser238的磷酸化。用Ser238 （SVIL-S238A）取代丙氨酸表达svil可抑制细胞分裂的进展。此外，在表达sil - s238a的细胞中，观察到细胞动力学沟的异常浸润。我们的研究结果表明，SVIL的磷酸化对于完成细胞分裂是必不可少的。

We found that Supervillin (SVIL) was localized to the central spindle during cytokinesis. The localization was dependent on the phosphorylation of Ser238 of SVIL. Expression ofSVIL with the substitution of Ser238 (SVIL-S238A) to alanine inhibited progression of cytokinesis. Furthermore, aberrant ingression of cytokinetic furrow was observed in SVIL-S238A expressing cells. Our results show that phosphorylation of SVIL is essential for the completion of cytokinesis.