Identification of localization factor for cadherin-catenin complex in epithelial cells

在本研究中，我们成功地分离了钙粘连蛋白缺失的小鼠F9细胞，作为鉴定上皮细胞因子的工具，从而确定了钙粘连蛋白-连环蛋白复合体在上皮细胞中的定位。利用钙粘连蛋白缺失的F9细胞，我们发现在未分化的F9细胞中可能存在一种新的黏附模式，这种黏附模式不依赖于基于肌动蛋白的细胞骨架。我们还提出了一个意想不到的因素的存在，它调节了非上皮细胞中钙粘附素-连环蛋白复合体的定位。

In this study, we succeeded in the isolation of cadherin‐catenin‐deficient mouse F9 cells as a tool to identify the epithelial factor, which determine the localization of cadherin‐catenin complex in epithelial cells. Using the cadherin‐catenin‐deficient F9 cells, we perceive the possibility that there is a novel adhesion mode in undifferentiated F9 cells, which is independent of actin‐based cytoskeletons. We also suggested the presence of an unexpected factor, which regulate localization of cadherin-catenin complex in non‐epithelial cells.