Novel cell signaling by different Gb3-binding marine lectins.

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A17kDa α-galactoside-binding lectin,MytiLec purified from the Mediterranean mussel was found to have a novel triple-tandem repeat structure. It recognized globotriose (Gb3)and appeared strong cell static activity againstGb3 expressing lymphoma Raji cells. Another α-galactoside-binding lectin, SAL,a member of SUEL/rhamnose-binding lectin family isolated from catfish eggdid not influence the growth of Raji cells, though it down-regulated the expression levels of the multidrug-resistanttransporter gene. Combining these results, it became clear that even lectins having same oligosaccharide binding specificity, can transmit different signals to cells according to the variations of their multivalency and dissociation constants. This new finding will be usefulto study the cellular functions of these lectins to regulate cell proliferation.