Alteration of number and type of myofiber of offspring by maternal nutritional regulation and postnatal thyroid manipulation

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Pregnant sows were fed a diet supplemented with arginine and glycine from day 25 to day 50 of the parturition. The piglets of the sows were orally given either thyroid hormone (T4) or an anti-thyroid agent (PTU) for 3 weeks from 1 day old. The supplementation of arginine and glycine to the maternal diet affected myosin heavy chain gene expression in longissimus dorsi muscle of the 1-day-old piglets. Further, we obtained evidence that thyroid hormone controlled ratio of type I myofiber of longissimus dorsi muscle in the pig during postnatal development.