Study on the role of CNP in the regulation of oocyte meiosis

本研究探讨了CNP/NPR2信号在卵母细胞减数分裂调控中的作用，得到了以下新发现：(1)CNP及其受体（NPR2）在卵巢颗粒细胞中表达；(2)NPR2基因突变小鼠在窦卵泡中表现出卵母细胞减数分裂提前恢复；(3)CNP响应LH信号下调。这些结果表明，卵母细胞减数分裂的抑制是由颗粒细胞发出的CNP/NPR2信号维持的，而LH信号则缓解了这一信号。

This study investigated the role of CNP/NPR2 signaling in the regulation of oocyte meiosis, and obtained novel findings as follows: (1) CNP and its receptor (NPR2) were expressed in ovarian granulosa cells (2) mice with a mutation in Npr2 gene showed precocious resumption of oocyte meiosis in antral follicles (3) CNP was downregulated in response to LH signaling. These results suggest that the arrest of oocyte meiosis is maintained by CNP/NPR2 signaling from the granulosa cells that is relieved by LH signaling.