Study on the role of CNP in the regulation of oocyte meiosis
Study on the role of CNP in the regulation of oocyte meiosis
批准号:
22580332
负责人:
TSUJI Takehito
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
本研究探讨了CNP/NPR2信号在卵母细胞减数分裂调控中的作用,得到了以下新发现:(1)CNP及其受体(NPR2)在卵巢颗粒细胞中表达;(2)NPR2基因突变小鼠在窦卵泡中表现出卵母细胞减数分裂提前恢复;(3)CNP响应LH信号下调。这些结果表明,卵母细胞减数分裂的抑制是由颗粒细胞发出的CNP/NPR2信号维持的,而LH信号则缓解了这一信号。
英文摘要
This study investigated the role of CNP/NPR2 signaling in the regulation of oocyte meiosis, and obtained novel findings as follows: (1) CNP and its receptor (NPR2) were expressed in ovarian granulosa cells (2) mice with a mutation in Npr2 gene showed precocious resumption of oocyte meiosis in antral follicles (3) CNP was downregulated in response to LH signaling. These results suggest that the arrest of oocyte meiosis is maintained by CNP/NPR2 signaling from the granulosa cells that is relieved by LH signaling.
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鉴定导致骨骼生长突变的基因 (dwg)
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Nakamuta, N., Kashihara, A., Okita, T., Shimizu, M. and Taniguchi, K., Kenta Watanabe, 度会雅久, 山田郁・辻 岳人]
通讯作者:
山田郁・辻 岳人
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sks突变小鼠粗线期精母细胞核形态异常
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[梶田晋平, その他]
通讯作者:
その他
The role of C-type natriuretic peptide in fat accumulation
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批准号:19780217
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.96万
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财政年份:2007
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负责人:TSUJI Takehito
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依托单位:
海外基金