Study on the role of CNP in the regulation of oocyte meiosis

本研究探讨了CNP/NPR 2信号通路在卵母细胞减数分裂调控中的作用，获得了如下新发现：（1）CNP及其受体（NPR 2）在卵巢颗粒细胞中表达;（2）NPR 2基因突变小鼠在有腔卵泡中表现出卵母细胞减数分裂的早熟恢复;这些结果表明，卵母细胞减数分裂的停滞是由来自颗粒细胞的CNP/NPR 2信号维持的，而颗粒细胞的CNP/NPR 2信号被LH信号缓解。

This study investigated the role of CNP/NPR2 signaling in the regulation of oocyte meiosis, and obtained novel findings as follows: (1) CNP and its receptor (NPR2) were expressed in ovarian granulosa cells (2) mice with a mutation in Npr2 gene showed precocious resumption of oocyte meiosis in antral follicles (3) CNP was downregulated in response to LH signaling. These results suggest that the arrest of oocyte meiosis is maintained by CNP/NPR2 signaling from the granulosa cells that is relieved by LH signaling.