Induction of alternative activation of macrophages and alterationsin intestinal epithelial cell function by Th2 cytokines for type 2 diabetes therapy

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KK-Ay/TaJｃl mice, an animal models of type 2 diabetes were inoculated with infective third-stage Heligmosomoides polygyrus (Hp) larvae and studied at day8 after infection. Th2 cytokine gene expression was elevated, and AAMacs were accumulated in the small intestine. The gene expression of GLUT-2 and SGLT-1 was down regulated. Helminth infection could reduce blood glucose level and the liver enzyme levels and improve a fatty liver. Inducing intestinal AAMacs by Hp infection could have therapeutic importance for T2D.