Antibacterial Drug Delivery by Surface Modified Nanoparticle forTreatment of Biofilm Infection Disease

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Biofilms increased resistance to detergents and antibiotics, as the dense extracellular matrix and the outer layer of cells protect the interior of the community. These biofilms cause the intractable infections. Therefore, the development of antibacterial drug delivery systems for treatment of biofilm infection disease is strongly desired. We intended to design surface modified PLGA nanoparticle for antibacterial drug delivery to the bacteria in the biofilm. CS-modified PLGA NP indicated the strongly antibacterial effect and suppression of biofilm formation. Because CS-modified NP could adsorb on the negatively charged biofilms and deliver antibacterial drug to biofilm formed with bacteria, in which the high concentration gradient of CAM was formed. Therefore, CS-modified PLGA NP has a high potential to be used in biofilm infection disease therapy.