Molecular cellular biology of the cell cycle progression under inhibition of Kinesin Spindle Protein

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Many targeted drugs with anti-cancer activity are being developed in academic institutes and pharmaceutical companies. Compounds with specific inhibition activity against a mitotic kinesin KSP are categorized in important candidates of such drugs. In this study, we have found a mitotic molecular event of microtubules whose dynamics were disorganized under treatment of the kinesin inhibitor, and shed light on the molecular mechanisms. From the results of these molecular cellular biological studies, we also demonstrated that the kinesin inhibitor prevent tissue culture cells from proliferating synergistically with anti-cancer drug Paclitaxel. Taken together, our results can facilitate understanding how inhibitors against the kinesin work on cancer cell proliferation, and contribute to planning new anti-cancer strategies using drugs.