Bronchial epithelial cells as the targets of the therapy for refractory asthma of elderly patients.

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Inhaled- steroid bring the great advance in the therapy of athma. However, as for an elderly's asthma, the impairment of a respiratory-epithelium cells and its structural change break out refractory cases from a severe airway inflammation and remodeling. So, in this study, we analyzed the therapeutic potential of the novel curcumin derivative and the endogenous ligand of the alpha7 subunit of nicotinic acetylcholine receptors, and clarified its effectiveness in airway inflammation and remodeling.