Role of G protein-coupled receptor kinase 5 in myocardial infarction

G蛋白偶联受体激酶（GRKs）最初被确定为磷酸化G蛋白偶联受体的分子，导致其脱敏。我们首先发现心肌梗死（MI）后左心室梗死区GRK5表达显著升高。我们随后检测了心肌梗死后WT和β-arrestin2 KO小鼠的死亡率，GRK5 KO小鼠比WT小鼠更容易死亡。

G protein-coupled receptor kinases (GRKs) were initially identified as molecules that phosphorylate G-protein coupled receptors, leading to their desensitization. We first found that GRK5 expression was significantly increased in the infarct area of left ventricle after myocardial infarction (MI). We next examined the mortality rate of WT and β-arrestin2 KO mice after MI. GRK5 KO mice were more prone to die than WT mice after MI.