New Antimalarial Drug Development Research

我发现了一些针对多重耐药恶性疟原虫的新型抗疟药物开发研究的结果。利用40种体内具有过氧化物结构的有机合成化合物和20种天然产物获得了少量具有1μM抗疟活性的恶性疟原虫（FCR-3）化合物。为了评价N-89在疟疾患者临床模型系统中的抗疟活性，N-89在超过5%的伯氏疟原虫感染小鼠模型中具有高且强的抗疟活性。制备了几种对小鼠血药浓度有长效作用的N-89配方。结果表明，不同剂型的N-89的抗疟活性较油-N-89弱，但未改变油-89在小鼠体内的药代动力学参数。

I found several results for new antimalarial drug development study against multi-drug resistant Plasmodium falciparum.1. A few numbers of compounds indicating the 1μM of antimalarial activity for P. falciparum (FCR-3 strain) were acquired using 40 kinds of organic synthetic compounds having peroxide structure in the body and 20 kinds of compounds from the natural product.2. To evaluate of antimalarial activity for N-89 in clinical model system of malaria patients, N-89 has high and strong antimalarial activity in more than 5% of parasitemia of P. bergheiinfected-mice model on oral route of it.3. I prepared several kinds of N-89 formula for long lasting effect in blood concentration of mice model. As results, the different formulation of N-89 has weak antimalarial activity compare of oil-N-89 but they did not changed pharmacokinetic parameters in mice compare of oil-N-89.