A Versatile method for the synthesis of DTPA bearing functionalized side chain toward the application to MRI clinical diagnosis

成功地实现了一种多功能的DTPA承载功能化侧链的合成方法。尽管DTPA框架中有5个反应点，但仅成功地将关键反应侧链引入DTPA。在侧链末端引入了官能团，并成功地将几个药效分子与官能团连接起来。用核磁共振谱仪测定了靶分子的核磁共振造影参数。给小鼠注射一种化合物，观察其核磁共振成像。

A versatile method for the synthesis of DTPA bearing functionalized side chain was successfully accomplished. Introduction of only one side chain to DTPA, the key reaction, was succeeded in spite of the five reacting points in DTPA framework. Introduction of functional group at the terminus of the side chain, and connection of several pharmacokintic molecules with the functionalgroup was also succeeded. A parameter for MRI contrast of the target molecule was measured by MRI spectrometer. A compound was injected to mice to observe MRI image.