Study for protective and harmful effects of environmental factors on emotional system and its development

环境因素对情绪系统及其发展的保护与有害作用研究

• 批准号: 22590118
• 负责人: SHIRASAKI Tetsuya
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590118/
• 关键词: 環境衛生学; 神経発達; 生後早期ストレス; 情動機能障害; 自然環境音; 疾病予防; 母仔隔離; 白色雑音刺激; モノアミン; GIRKチャネル; 腹側被蓋; 海馬CA1; パッチクランプ; 行動科学試験; 環境; 衛生薬学; 神経科学; ストレス; 生理学

We studied how environmental factors in early life stage affectemotional brain functions by using electrophysiological, neurochemical and behavioralscience techniques. Psychologically stressful environments alter receptor functions tomonoamines and/or amino acids or responsiveness to them. Expression levels of GIRK2 and5-HT1Areceptor were not affected. Short but repeated maternal isolation tended to increaseaggressive behavior. Environmental natural sounds such as sounds of a stream protectedfrom the effects observed at single neuron level of short but repeated maternal isolation.

我们研究了早期生命阶段的环境因素如何通过使用电生理，神经化学和行为科学技术来情感脑功能。心理压力的环境会改变受体功能tomonoamines和/或氨基酸或对它们的反应。 GIRK2和5-HT1AREPEDOR的表达水平不受影响。短而重复的母体隔离往往会增加索行为。环境自然的声音，例如溪流的声音，从短而反复的母体隔离的单个神经元水平上观察到的效果。

项目成果

Effectsof early life stress on ionic currentsin the CNS neurons and neuro-behaviorsand its attenuation by natural sounds

早期生活压力对中枢神经系统神经元离子电流和神经行为的影响及其对自然声音的衰减

• 发表时间: 2012
• 作者: Tetsuya Shirasaki;Ryota Hamasaki,Fumio Soeda;Kazuo Takahama
• 通讯作者: Kazuo Takahama

Effects of early life stress on ionic currents in the CNS neurons and behavior and amelioration by exposure to natural sounds.

早期生活压力对中枢神经系统神经元离子电流和行为的影响以及通过接触自然声音得到的改善。

• 发表时间: 2012
• 作者: Tetsuya Shirasaki;Ryota Hamasaki;Fumio Soeda;Kazuo Takahama.
• 通讯作者: Kazuo Takahama.