Phase Control of Circadian Rhythms by Heme as a Key Molecule

血红素作为关键分子对昼夜节律的相位控制

• 批准号: 22590121
• 负责人: MITSUMOTO Atsushi
• 金额: $ 3.16万
• 依托单位: Josai International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590121/
• 关键词: 中毒学; 概日リズム; 生物時計; 化学物質中毒; ヘム; ポルフィリン症; グリセオフルビン; 疾病モデル動物; 位相

We have investigated the role of heme as a key molecule to control the phase of circadian rhythms in mice, using griseofulvin-induced porphyria model. Our research product has recently been published in Am J Physiol. Moreover, we advanced the research project based on the difference of drug sensitivity of the mice, we have established the model mice of alcohol dependence, and found that some substances could work as therapeutic and preventive drug for the disease.

我们利用灰黄霉素诱导的卟啉症模型，研究了血红素作为控制小鼠昼夜节律阶段的关键分子的作用。我们的研究产品最近发表在《Am J Physiol》上。此外，我们根据小鼠对药物敏感性的差异提出了研究方案，建立了小鼠酒依赖模型，发现一些物质可以作为治疗和预防该病的药物。

项目成果

Up-Regulation of Stearoyl-CoA Desaturase 1 Increases Liver MUFA Content in Obese Zucker but Not Goto-Kakizaki Rats

• DOI: 10.1007/s11745-013-3786-2
• 发表时间: 2013-05-01
• 期刊: LIPIDS
• 影响因子: 1.9
• 作者: Karahashi, Minako;Ishii, Fumiko;Kudo, Naomi
• 通讯作者: Kudo, Naomi

Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice.

血红素生物合成受损会导致小鼠体温节律缩短。

• DOI: 10.1152/ajpregu.00019.2011
• 发表时间: 2012
• 期刊: Am J Physiol Regul Integr Comp Physiol.
• 作者: Iwadate R;Satoh Y;Watanabe Y;Kawai H;Kudo N;Kawashima Y;Mashino T;Mitsumoto A.
• 通讯作者: Mitsumoto A.

Effects of Perfluorinated Fatty Acids with Different Carbon Chain Length on Fatty Acid Profiles of Hepatic Lipids in Mice

• DOI: 10.1248/bpb.34.856
• 发表时间: 2011-06-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Kudo, Naomi;Yamazaki, Tohru;Kawashima, Yoichi
• 通讯作者: Kawashima, Yoichi

Differential Induction of Stearoyl-CoA Desaturase 1 and 2 Genes by Fibrates in the Liver of Rats

贝特类药物对大鼠肝脏硬脂酰辅酶A去饱和酶1和2基因的差异诱导

• DOI: 10.1248/bpb.35.116
• 发表时间: 2012
• 期刊: Biological and Pharmaceutical Bulletin
• 影响因子: 2
• 作者: Yamazaki;T.;Okada;H.;Sakamoto;T;Sunaga;K.;Tsuda;T.;Mitsumoto;A.;Kudo;N. and Kawashima;Y
• 通讯作者: Y

６年制薬学生のヒューマニズム教育による意識変容

药学六年级学生人文教育意识的转变

• 发表时间: 2013
• 作者: ○小柳順一;中村洋;亀井美子;新垣知輝;秋元雅之;光本篤史
• 通讯作者: 光本篤史