Phase Control of Circadian Rhythms by Heme as a Key Molecule

我们利用灰黄霉素诱导的小鼠卟啉病模型，研究了血红素作为控制昼夜节律时相的关键分子的作用。我们的研究成果最近发表在《美国生理学杂志》上。此外，我们根据小鼠对药物敏感性的差异提出了研究项目，建立了酒精依赖小鼠模型，发现某些物质可以作为酒精依赖的治疗和预防药物。

We have investigated the role of heme as a key molecule to control the phase of circadian rhythms in mice, using griseofulvin-induced porphyria model. Our research product has recently been published in Am J Physiol. Moreover, we advanced the research project based on the difference of drug sensitivity of the mice, we have established the model mice of alcohol dependence, and found that some substances could work as therapeutic and preventive drug for the disease.