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Changes in emotional and learning behavior evoked by environmentalstress; role of microglia in the brain

Changes in emotional and learning behavior evoked by environmentalstress; role of microglia in the brain
环境压力引起的情绪和学习行为的变化;
批准号:
22590225
负责人:
KATAFUCHI Toshihiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
(1) Impairment of learning and memory and fatigue in rats induced by peripheral infection stresses were blocked by minocycline, which is known to suppress activation of microglia. (2) Application of Il-1β to primary culture of rat astrocytes induces expression of serotonin transporters. (3) Poly I:C-induced impairment of water maze test in rats was due to IL-6, which expressed in the hippocampus. (4) Everyday injection of LPS (i.p.) in adult mice for 7 days induced accumulation ofβamyloid protein in the hippocampus and prefrontal cortex, which was attenuated by co-application of plasmalogens.
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会议论文
Plasmalogens attenuate lipopolysaccharide-induced β-amyloid accumulation in mice
缩醛磷脂可减弱脂多糖诱导的小鼠 β-淀粉样蛋白积累
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Katafuchi, T., Ifuku, M, Fujino, T., Shiro Mawatari]
通讯作者: Shiro Mawatari
Introduction : advances in neuroimmune biology : a comprehensive way to look at biology
简介:神经免疫生物学的进展:看待生物学的综合方法
DOI: 10.3233/nib-2011-001
发表时间: 2011
期刊: Adv.Neuroimmuns Biol.
影响因子: --
作者: [Berczi, I., Katafuchi, T]
通讯作者: T
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Katafuchi, T., Ifuku, M. and Take, S]
通讯作者: S
免疫学的疲労モデル動物における脳内炎症機序
免疫疲劳模型动物的脑内炎症机制
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [片渕俊彦, 井福正隆]
通讯作者: 井福正隆
20
    Mechanisms of pain-induced emotion and its effects on learning and memory
    • 批准号:
      19603004
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2007
    • 负责人:
      KATAFUCHI Toshihiko
    • 依托单位:
    Brain mechanism and conditioning of emotional behavior induced by immunological stress
    • 批准号:
      17590207
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      KATAFUCHI Toshihiko
    • 依托单位:
    Analysis of adaptation mechanisms during environmental stress through the neural-immune interaction.
    • 批准号:
      12470011
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.09万
    • 财政年份:
      2000
    • 负责人:
      KATAFUCHI Toshihiko
    • 依托单位:
    Roles of brain mast cells and their related substances in the central mechanisms of stress responses
    • 批准号:
      10557008
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $7.55万
    • 财政年份:
      1998
    • 负责人:
      KATAFUCHI Toshihiko
    • 依托单位:
    海外基金