Functional analysis of CIBZ, a methyl-CpG binding protein which is essential for the ES cell differentiation

CIBZ 的功能分析，CIBZ 是 ES 细胞分化所必需的甲基 CpG 结合蛋白

• 批准号: 22590272
• 负责人: MATSUDA Eishou
• 金额: $ 2.91万
• 依托单位: Nara Institute of Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590272/
• 关键词: ES 細胞; 細胞増殖; 細胞分化; 細胞周期; DNA メチル化; 筋芽細胞分化; 胚性幹（ES）細胞; DNAメチル化; メチル化DNA結合タンパク質; 転写後修飾; Nanog; ES細胞; 細胞死; 転写制御

G1/S transition is important for embryonic stem cell (ESC) proliferation; however, the transcriptional factor that regulates this remains largely unknown. We present data showing that CIBZ, a transcription factor, regulates ESC proliferation and G1/S transition. Our results indicate that CIBZ-associated ESC proliferation and G1/S transition is dependent on Nanog expression.

G1/S转换对于胚胎干细胞（ESC）增殖是重要的;然而，调控这一转换的转录因子在很大程度上仍然未知。我们目前的数据表明，CIBZ，转录因子，调节ESC增殖和G1/S转换。我们的研究结果表明，CIBZ相关的ESC增殖和G1/S转换依赖于Nanog表达。

项目成果

The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression

• DOI: 10.1038/cr.2011.90
• 发表时间: 2011-11-01
• 期刊: CELL RESEARCH
• 影响因子: 44.1
• 作者: Oikawa, Yu;Omori, Reiko;Matsuda, Eishou
• 通讯作者: Matsuda, Eishou

DNA methylation and myoblast differentiation: role of a new methyl-binding protein

DNA甲基化和成肌细胞分化：新甲基结合蛋白的作用

• 发表时间: 2011
• 作者: Yamashita K;Miyoshi T;Arai Y;Mizugishi K;Takaori-Kondo A;Ueyama T;松田永照
• 通讯作者: 松田永照

CtBP-interacting BTB Zinc Finger Protein (CIBZ) Promotes Proliferation and G1/S Transition in Embryonic Stem Cells via Nanog

• DOI: 10.1074/jbc.m111.333856
• 发表时间: 2012-04-06
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Nishii, Tomonori;Oikawa, Yu;Matsuda, Eishou
• 通讯作者: Matsuda, Eishou