Role of Wnt signal modulators in malignancy of cancer
Role of Wnt signal modulators in malignancy of cancer
批准号:
22590282
负责人:
UCHIDA Kazuhiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
In this study, we analyzed the mechanisms of Wnt signaling modulator in carcinogenesis and malignant transformation. We have found overexpression of novel Wnt modulator. Membrane Protein X (MPX) by ‘omics’ analysis of liver cancer. Functional analysis of MPX by over-expression of cDNA and siRNA knockdown for MPX revealed this new Wnt signaling modulator promote cancer invasion in liver cancer.
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Peptidomic and immunological analyses reveal novel circulating biomarkers for nonalcoholic fatty liver diseases
肽组学和免疫学分析揭示了非酒精性脂肪肝疾病的新型循环生物标志物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Korenaga T., Uchida, K, et al.]
通讯作者:
et al.
DOI:
10.3892/ijo.2012.1752
发表时间:
2013-02-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Shimazui, Toru, Yoshikawa, Kazuhiro, Nishiyama, Hiroyuki]
通讯作者:
Nishiyama, Hiroyuki
New Strategy for Identification and Assay Development of Circulating Peptide Biomarkers for Chronic Liver Disease and Hepatocellular Carcinoma
慢性肝病和肝细胞癌循环肽生物标志物鉴定和检测开发的新策略
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Uchida, K.]
通讯作者:
K.
Quantitative Peptidomic Analysis Reveals Novel Circulating Biomarkers for Chronic Inflammation in Transaminase-Negative Chronic Hepatitis and Nonalcoholic Fatty Liver Disease.
定量肽组学分析揭示了转氨酶阴性慢性肝炎和非酒精性脂肪肝中慢性炎症的新型循环生物标志物。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suzuki, H., Meno, K., Korenaga, T., Ishii, T., Sugimoto, K., Nagashima, R., Shiraki, K., Uchida, K]
通讯作者:
K
Pooled Sampleを用いた血清中のNASHバイオマーカーペプチドのiTRAQによる同定
使用合并样本对血清中的 NASH 生物标志物肽进行 iTRAQ 鉴定
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[杉本和史, 山本憲彦, 白木克哉, 竹井謙之, 熊田卓, 内田和彦]
通讯作者:
内田和彦
共 18 条
Mechanisms of the spindle assembly checkpoint silencing by kinetochore stretching
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批准号:22770200
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
-
财政年份:2010
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负责人:UCHIDA Kazuhiko
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依托单位:
Research for signal transduction factors in carcinogenesis by differential proteomics analysis
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批准号:18590506
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.57万
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财政年份:2006
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负责人:UCHIDA Kazuhiko
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依托单位:
Genetic network analysis of INF-α treatment in hepatitis C virus-related hepatocellular carcinoma
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批准号:15310137
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.18万
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财政年份:2003
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负责人:UCHIDA Kazuhiko
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依托单位:
Identification of novel oncogenes invloved in onset and progression of cancers with poor prognosis.
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批准号:09670145
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:UCHIDA Kazuhiko
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依托单位:
海外基金